Idebenone
Antioxidant
Idebenone is a type of antioxidant that helps protect cells from damage caused by free radicals. It's often used in skincare products to reduce the appearance of fine lines and wrinkles.
Moderate Concern
Source: EWG Skin Deep
Idebenone has been linked to some skin irritation and allergic reactions, but it's generally considered safe when used as directed.

ENOUGH with this skincare scam.
Dr. Sam Ellis
r/tretinoin
5
[Routine Help] Acclimating to Daily Tretinoin Usage
Therapeutic benefit of idebenone in Leber hereditary optic neuropathy: a systematic review and meta-analysis.
Ribeiro PVZ, Pari Mitre L, Gauza MM
2025
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Last updated: May 16, 2026